miRNA expression in the failing human heart: functional correlates.

  title={miRNA expression in the failing human heart: functional correlates.},
  author={Carmen C. Sucharov and Michael R. Bristow and J. David Port},
  journal={Journal of molecular and cellular cardiology},
  volume={45 2},
MicroRNAs (miRNAs) are small, noncoding ~22-nucleotide regulatory RNAs that are key regulators of gene expression programs. Their role in the context of the cardiovascular system has only recently begun to be explored; however, changes in the expression of miRNAs have been associated with cardiac development and with several pathophysiological states including myocardial hypertrophy and heart failure. We demonstrate that miRNA expression patterns are distinct in two types of heart failure… CONTINUE READING

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