miRNA arm selection and isomiR distribution in gastric cancer

  title={miRNA arm selection and isomiR distribution in gastric cancer},
  author={Sung-Chou Li and Yu-Lun Liao and Meng-Ru Ho and Kuo-Wang Tsai and Chun-Hung Lai and Wen-chang Lin},
  booktitle={BMC Genomics},
MicroRNAs (miRNAs) are small non-protein-coding RNAs. miRNA genes need several biogenesis steps to form function miRNAs. However, the precise mechanism and biology involved in the mature miRNA molecules are not clearly investigated. In this study, we conducted in-depth analyses to examine the arm selection and isomiRs using NGS platform. We sequenced small RNAs from one pair of normal and gastric tumor tissues with Solexa platform. By analyzing the NGS data, we quantified the expression… CONTINUE READING
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