miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma

@article{Veija2014miRNA34aUI,
  title={miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma},
  author={Tuukka Veija and Helka Sahi and Virve S. Koljonen and Tom Bohling and Sakari Knuutila and Neda Mosakhani},
  journal={Virchows Archiv},
  year={2014},
  volume={466},
  pages={289-295}
}
Merkel cell polyomavirus (MCV) is frequently detectable in Merkel cell carcinoma (MCC) tumors, but the significance of MCV infection is not yet totally understood. Thus far, no key regulatory miRNA has been identified for MCC tumorigenesis. However, distinct miRNA expression profiles have been suggested for MCV-positive and MCV-negative tumors. We used microarray hybridization to identify miRNA expression differences in MCC tumor samples according to MCV status and further validated these… CONTINUE READING

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