miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma.

@article{Kasinski2012miRNA34PC,
  title={miRNA-34 prevents cancer initiation and progression in a therapeutically resistant K-ras and p53-induced mouse model of lung adenocarcinoma.},
  author={Andrea L Kasinski and Frank J. Slack},
  journal={Cancer research},
  year={2012},
  volume={72 21},
  pages={5576-87}
}
Lung cancer is the leading cause of cancer deaths worldwide, and current therapies fail to treat this disease in the vast majority of cases. The RAS and p53 pathways are two of the most frequently altered pathways in lung cancers, with such alterations resulting in loss of responsiveness to current therapies and decreased patient survival. The microRNA-34 (mir-34) gene family members are downstream transcriptional targets of p53, and miR-34 expression is reduced in p53 mutant tumors; thus, we… CONTINUE READING

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EGFR andMET receptor tyrosine kinase - alteredmicroRNAexpression induces tumorigenesis and ge fi tinib resistance in lung cancers

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