miRNA-29c Suppresses Lung Cancer Cell Adhesion to Extracellular Matrix and Metastasis by Targeting Integrin β1 and Matrix Metalloproteinase2 (MMP2)

Abstract

Our pilot study using miRNA arrays found that miRNA-29c (miR-29c) is differentially expressed in the paired low-metastatic lung cancer cell line 95C compared to the high-metastatic lung cancer cell line 95D. Bioinformatics analysis shows that integrin β1 and matrix metalloproteinase 2 (MMP2) could be important target genes of miR-29c. Therefore, we… (More)
DOI: 10.1371/journal.pone.0070192

Topics

7 Figures and Tables

Cite this paper

@inproceedings{Wang2013miRNA29cSL, title={miRNA-29c Suppresses Lung Cancer Cell Adhesion to Extracellular Matrix and Metastasis by Targeting Integrin β1 and Matrix Metalloproteinase2 (MMP2)}, author={Heyong Wang and Yingchao Zhu and Mingchuan Zhao and Chunlian Wu and Peng Zhang and Liang Tang and Huijun Zhang and Xiaofeng Chen and Yaoqin Yang and Gentao Liu}, booktitle={PloS one}, year={2013} }