miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1

@inproceedings{Rebucci2015miRNA196bIC,
  title={miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1},
  author={Magali Rebucci and Audrey Sermeus and Elodie Leonard and Edouard Delaive and Marc Dieu and Maude Fransolet and Thierry Arnould and Carine Michiels},
  booktitle={Molecular Cancer},
  year={2015}
}
Tumor hypoxia is one of the features of tumor microenvironment that contributes to chemoresistance. miRNAs have recently been shown to play important roles in tumorigenesis and drug resistance. Moreover, hypoxia also regulates the expression of a series of miRNAs. However, the interaction between chemoresistance, hypoxia and miRNAs has not been explored yet. The aim of this study is to understand the mechanisms activated/inhibited by miRNAs under hypoxia that induce resistance to chemotherapy… CONTINUE READING
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