miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.

@article{AlvarezSaavedra2011miRNA132OC,
  title={miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock.},
  author={Mat{\'i}as Alvarez-Saavedra and Ghadi Antoun and Akiko Yanagiya and Reynaldo Oliva-Hernandez and Daniel Cornejo-Palma and Carolina Perez-Iratxeta and Nahum Sonenberg and Hai-Ying Mary Cheng},
  journal={Human molecular genetics},
  year={2011},
  volume={20 4},
  pages={731-51}
}
Mammalian circadian rhythms are synchronized to the external time by daily resetting of the suprachiasmatic nucleus (SCN) in response to light. As the master circadian pacemaker, the SCN coordinates the timing of diverse cellular oscillators in multiple tissues. Aberrant regulation of clock timing is linked to numerous human conditions, including cancer, cardiovascular disease, obesity, various neurological disorders and the hereditary disorder familial advanced sleep phase syndrome… CONTINUE READING
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