miRNA-132-3p inhibits osteoblast differentiation by targeting Ep300 in simulated microgravity

  title={miRNA-132-3p inhibits osteoblast differentiation by targeting Ep300 in simulated microgravity},
  author={Zebing Hu and Yixuan Wang and Zhongyang Sun and Han Wang and Hua Zhou and Lianchang Zhang and Shuhong Zhang and Xinsheng Cao},
  booktitle={Scientific reports},
Recent studies have demonstrated that miRNAs can play important roles in osteoblast differentiation and bone formation. However, the function of miRNAs in bone loss induced by microgravity remains unclear. In this study, we investigated the differentially expressed miRNAs in both the femur tissues of hindlimb unloading rats and primary rat osteoblasts (prOB) exposed to simulated microgravity. Specifically, miR-132-3p was found up-regulated and negatively correlated with osteoblast… CONTINUE READING
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The authors declare no competing financial interests

  • Eskildsen, T. et al. MicroRNA-138 regulates osteogenic different 108, +9 authors Z. S. prepared the figures. Z.H. wrote the paper. All interests
  • How to cite this article: Hu, Z. et al. miRNA-132…
  • 2015

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