miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

  title={miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning},
  author={Duygu Kuzuoğlu-{\"O}zt{\"u}rk and Dipankar Bhandari and E. Huntzinger and M. Fauser and S. Helms and E. Izaurralde},
  journal={The EMBO Journal},
  pages={1186 - 1203}
  • Duygu Kuzuoğlu-Öztürk, Dipankar Bhandari, +3 authors E. Izaurralde
  • Published 2016
  • Medicine, Biology
  • The EMBO Journal
  • miRNAs associate with Argonaute (AGO) proteins to silence the expression of mRNA targets by inhibiting translation and promoting deadenylation, decapping, and mRNA degradation. A current model for silencing suggests that AGOs mediate these effects through the sequential recruitment of GW182 proteins, the CCR4–NOT deadenylase complex and the translational repressor and decapping activator DDX6. An alternative model posits that AGOs repress translation by interfering with eIF4A function during… CONTINUE READING
    HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs
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