miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning

@inproceedings{Kuzuoluztrk2016miRISCAT,
  title={miRISC and the CCR4–NOT complex silence mRNA targets independently of 43S ribosomal scanning},
  author={Duygu Kuzuoğlu‐{\"O}zt{\"u}rk and Dipankar Bhandari and Eric Huntzinger and Maria Fauser and Sigrun Helms and Elisa Izaurralde},
  booktitle={The EMBO journal},
  year={2016}
}
miRNAs associate with Argonaute (AGO) proteins to silence the expression of mRNA targets by inhibiting translation and promoting deadenylation, decapping, and mRNA degradation. A current model for silencing suggests that AGOs mediate these effects through the sequential recruitment of GW182 proteins, the CCR4-NOT deadenylase complex and the translational repressor and decapping activator DDX6. An alternative model posits that AGOs repress translation by interfering with eIF4A function during… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…