miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.

@article{Cimino2013miR148bIA,
  title={miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1.},
  author={Daniela Cimino and Cristiano De Pitt{\`a} and Francesca Orso and Matteo Zampini and Silvia Casara and Elisa Penna and Elena Quaglino and Marco Forni and Christian Damasco and Eva Pinatel and Riccardo Ponzone and Chiara Romualdi and Cathrin Brisken and Michele De Bortoli and Nicoletta Biglia and Paolo Provero and Gerolamo Lanfranchi and Daniela Taverna},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 3},
  pages={1223-35}
}
Breast cancer is often fatal during its metastatic dissemination. To unravel the role of microRNAs (miRs) during malignancy, we analyzed miR expression in 77 primary breast carcinomas and identified 16 relapse-associated miRs that correlate with survival and/or distinguish tumor subtypes in different datasets. Among them, miR-148b, down-regulated in aggressive breast tumors, was found to be a major coordinator of malignancy. In fact, it is able to oppose various steps of tumor progression when… CONTINUE READING