miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions.

@article{Rom2015miR98AL,
  title={miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions.},
  author={Slava Rom and Holly Dykstra and Viviana Zuluaga-Ramirez and Nancy L. Reichenbach and Yuri Persidsky},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2015},
  volume={35 12},
  pages={1957-65}
}
Pathologic conditions in the central nervous system, regardless of the underlying injury mechanism, show a certain level of blood-brain barrier (BBB) impairment. Endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation due to stroke, atherosclerosis, trauma, or brain infections. Recently, microRNAs (miRNAs) have emerged as a class of gene expression regulators. The relationship between neuroinflammation and miRNA expression in brain endothelium… CONTINUE READING
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