miR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells

Abstract

MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.

DOI: 10.1007/s11010-014-1966-x

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@article{Guo2014miR96DR, title={miR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells}, author={Haizhou Guo and Qianping Li and Weihao Li and Tianliang Zheng and Song Zhao and Zhang-suo Liu}, journal={Molecular and Cellular Biochemistry}, year={2014}, volume={390}, pages={155-160} }