miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans

@inproceedings{Budziska2016miR96MA,
  title={miR-96, miR-145 and miR-9 expression increases, and IGF-1R and FOXO1 expression decreases in peripheral blood mononuclear cells of aging humans},
  author={Monika Budzińska and Magdalena Owczarz and Eliza Pawlik-Pachucka and Malgorzata Roszkowska-Gancarz and Przemyslaw Slusarczyk and M Puzianowska-Kuźnicka},
  booktitle={BMC geriatrics},
  year={2016}
}
BACKGROUND In mammals, the IGF-1 pathway affects the phenotype of aging. Since the function of the immune system is modulated by IGF-1, it is plausible that immunosenescence might in part result from altered control by this pathway. We therefore examined whether the expression of IGF-1R, FOXO1, and FOXO3a in peripheral blood mononuclear cells (PBMC) changes with age and if this might be due to changes in the expression of select miRNAs. METHODS The expression of IGF-1R, FOXO1, FOXO3a, as well… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 65 references

BMC Geriatrics (2016

  • 2016
1 Excerpt

Similar Papers

Loading similar papers…