miR-886-3p levels are elevated in Friedreich ataxia.

@article{Mahishi2012miR8863pLA,
  title={miR-886-3p levels are elevated in Friedreich ataxia.},
  author={Lata H Mahishi and Ronald P. Hart and David R Lynch and Rajiv R Ratan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 27},
  pages={
          9369-73
        }
}
Friedreich ataxia (FRDA) is the most common inherited ataxia caused primarily by an intronic GAA.TTC triplet repeat expansion in the frataxin (FXN) gene. FXN RNA and protein levels are reduced in patients leading to progressive gait and limb ataxia, sensory loss, reduced tendon reflexes, dysarthria, absent lower limb reflexes, and loss of position and vibration sense. Neurological manifestations ensue from primary loss of dorsal root ganglia neurons and their associated axons ascending… CONTINUE READING
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