miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4.

@article{Okuda2013miR7SB,
  title={miR-7 suppresses brain metastasis of breast cancer stem-like cells by modulating KLF4.},
  author={H. Okuda and F. Xing and P. R. Pandey and Sambad Sharma and M. Watabe and S. K. Pai and Y. Mo and M. Iiizumi-Gairani and S. Hirota and Yin Liu and Kerui Wu and R. Pochampally and K. Watabe},
  journal={Cancer research},
  year={2013},
  volume={73 4},
  pages={
          1434-44
        }
}
Despite significant improvement in survival rates of patients with breast cancer, prognosis of metastatic disease is still dismal. Cancer stem-like cells (CSC) are considered to play a role in metastatic progression of breast cancer; however, the exact pathologic role of CSCs is yet to be elucidated. In this report, we found that CSCs (CD24(-)/CD44(+)/ESA(+)) isolated from metastatic breast cell lines are significantly more metastatic than non-CSC populations in an organ-specific manner. The… Expand
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