miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer.

@article{Tan2016miR6715pIE,
  title={miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer.},
  author={Xiaohui Tan and Yebo Fu and Liang Chen and Woojin Lee and Yinglei Lai and Katayoon Rezaei and Sana O. Tabbara and Patricia S Latham and Christine B. Teal and Yan-gao Man and Robert S. Siegel and Rachel F Brem and Sidney W. Fu},
  journal={Oncotarget},
  year={2016},
  volume={7 1},
  pages={293-307}
}
MicroRNA (miRNA) dysfunction is associated with a variety of human diseases, including cancer. Our previous study showed that miR-671-5p was deregulated throughout breast cancer progression. Here, we report for the first time that miR-671-5p is a tumor-suppressor miRNA in breast tumorigenesis. We found that expression of miR-671-5p was decreased significantly in invasive ductal carcinoma (IDC) compared to normal in microdissected formalin-fixed, paraffin-embedded (FFPE) tissues. Forkhead Box M1… CONTINUE READING
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Cancerassociated fibroblasts induce epithelial-mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

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