miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation.

@article{Hashemi2016miR608RC,
  title={miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation.},
  author={Mohammad Hashemi and Sara Sanaei and Maryam Rezaei and Gholamreza Bahari and Seyed Mehdi Hashemi and Mohammad Ali Mashhadi and Mohsen Taheri and S Ghavami},
  journal={Experimental oncology},
  year={2016},
  volume={38 1},
  pages={
          57-9
        }
}
AIM MicroRNAs (miRNAs) are small noncoding RNAs that function as oncogene or tumor suppressors. The single nucleotide polymorphisms in miRNAs potentially can alter miRNA-binding sites on target genes as well as affecting miRNAs expression. The present study aimed to evaluate the impact of miR-608 rs4919510 C>G variant on breast cancer (BC) risk. MATERIALS AND METHODS This case-control study conducted on 160 women with BC and 192 age-matched healthy women. Genotyping of miR-608 rs4919510 was… 
MiR-608 rs4919510 C>G polymorphism increased the risk of bladder cancer in an Iranian population
TLDR
The findings proposed that miR-608 polymorphism might be associated with increased risk of bladder cancer in a sample of Iranian population and further large-scale studies with different ethnicities are needed to verify the findings.
The Relationship Between miR-423 Genetic Variation and Women Breast Cancer Risk In the North of Iran
TLDR
The data demonstrated that miR-423 rs6505162 should be a protective factor for breast cancer, and further studies involving different ethnicities are required to verify the conclusion.
Association of a potential functional mir-520f rs75598818 G > A polymorphism with breast cancer
Some of the single-nucleotide polymorphisms in miRNA genes have been studied to date to find their association with the risk of breast cancer (BC). However, no study has been conducted to investigate
3-bp indel polymorphism (rs57408770) within pre-miR-3131 on PCa susceptibility in a sample of an Iranian population. Patients and methods
TLDR
It is proposed for the first time that a 3-bp indel variant of miR-3131 may be a risk factor for susceptibility to PCa in a sample of an Iranian population and further studies with different ethnicities and larger sample sizes are required.
The role of microRNA-608 polymorphism on the susceptibility and survival of cancer: a meta-analysis
TLDR
The meta-analysis suggested that the microRNA-608 rs4919510 polymorphism maybe associate with a significantly decreased risk for colorectal cancer, and further investigations on larger populations are required to evaluate and confirm this relationship.
The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type
TLDR
Evidence is provided that the miR-608 rs4919510 polymorphism may modify cancer susceptibility in a type-specific manner and SEMA4G may function as an oncogene or tumour suppressor to regulate tumour development in atype- specific manner.
The Relationship between Pre-miR-3131 3-bp Insertion/Deletion Polymorphism and Susceptibility and Clinicopathological Characteristics of Patients with Breast Cancer
TLDR
The findings did not support a relationship between pre-miR-3131 3-bp ins/del polymorphism and the risk of BC, while, this variant was significantly related to late onset BC.
Association between single-nucleotide polymorphisms in miRNA and breast cancer risk: an updated review
TLDR
This review analyzes the results of association studies between miRNA SNPs and BC risk from countries around the world and concludes that the effect of an SNP on BC risk depends on the ethnicity of the population.
Five Common Functional Polymorphisms in microRNAs and Susceptibility to Breast Cancer: An Updated Meta-Analysis.
TLDR
The present study indicates that only the rs895819 polymorphism was associated with BC risk, and the other four polymorphisms were not associated withBC risk in any of the models.
A meta-analysis: Is there any association between MiR-608 rs4919510 polymorphism and breast cancer risks?
TLDR
In the present meta-analysis, no relationships between miR-608 rs4919510 polymorphism (C>G) and the risk of breast cancer were found.
...
...