miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs

  title={miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs},
  author={Nasha Zhang and Yankang Li and Yan Zheng and Li Zhang and Yuan Pan and Jinming Yu and Ming Yang},
  journal={Laboratory Investigation},
Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptors (EGFR) significantly prolong the survival of lung adenocarcinoma patients with sensitizing EGFR mutations. Unfortunately, 10–30% patients do not show objective responses to EGFR-TKIs, and undergo rapid disease progression during the EGFR-TKIs therapy. Single nucleotide polymorphisms (SNPs) in mature microRNA (miRNA) sequences may influence target site interactions and modulate downstream pathways, such as the EGFR… 
miR-1262 Transcriptionally Modulated by an Enhancer Genetic Variant Improves Efficiency of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Advanced Lung Adenocarcinoma.
The data indicate that miR-1262 may be a potential therapeutic target for NSCLC, and the rs12740674 T allele was significantly associated with short survival time in both cohorts.
Oncogene HSPH1 modulated by the rs2280059 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.
In vitro and In vivo assays elucidated that rs2280059 G allele shows higher capability to drive HSPH1 promoter activities, which may lead to better understanding and outcome assessment of EGFR-TKI treatment.
Expression of MiR-608 in Nonsmall Cell Lung Cancer and Molecular Mechanism of Apoptosis and Migration of A549 Cells
MiR-608 expression was downregulated in the tumor tissue of NSCLC patients, while the transcription factor activating enhancer-binding protein 4 (TFAP4) expression was upregulated, and the findings can contribute to the effective treatment of NS CLC patients.
MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells
The present review paves the way for introducing a panel of miRNAs for the prediction of TKIs responses in lung cancer patients.
LncRNAs LCETRL3 and LCETRL4 at chromosome 4q12 diminish EGFR-TKIs efficiency in NSCLC through stabilizing TDP43 and EIF2S1
A novel model that integrates two lncRNAs transcribed from the 4q12 locus into the regulation of EGFR-TKIs resistance in NSCLC is revealed, shedding new light on the importance of functionally annotating lnc RNAs in the GWAS loci and provided insights to declare novel druggable targets.
miR-1262 suppresses gastric cardia adenocarcinoma via targeting oncogene ULK1
Findings demonstrate miR-1262 transcriptionally modulated by an enhancer genetic variant suppresses GCA via targeting oncogene ULK1 and highlights miR -1262 as a promising diagnostic marker and therapeutic target for GCA.
miR-4513 promotes breast cancer progression through targeting TRIM3.
The biological function of microRNA-4513 (miR-4513) in human cancers is emerging. However, it remains unknown whether miR-4513 has a role in breast cancer (BC). In this study, we analyzed the
Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments
Whether autophagy inhibition, along with anti-EGFR treatments, might represent a promising approach to overcome resistance to anti- EGFR treatments in various cancers is assessed.


MicroRNA-related genetic variants associated with clinical outcomes in early-stage non-small cell lung cancer patients.
Results indicate that miRNA-related polymorphisms may be associated with NSCLC patients' clinical outcomes through altered miRNA regulation of target genes.
Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma
It is suggested that loss of tumor-suppressive miR-29s enhanced cancer cell invasion in lung SCC through direct regulation of oncogenic LOXL2.
Polymorphisms in microRNA genes as predictors of clinical outcomes in colorectal cancer patients.
It is confirmed that variations in miRNA-encoding genes may be an important factor for modulating CRC prognosis and predicting therapy response.
miR-608 regulates apoptosis in human lung adenocarcinoma via regulation of AKT2.
It is presented the first evidence that miR-608 behaves as a tumour suppressor in A549 and SK-LU-1 cells through the regulation of AKT2, suggesting that selective targeting ofAKT2 via mi R-608 may be developed as a potential therapeutic strategy for miRNA-based non-small cell lung cancer (NSCLC) therapy.
Identification of miR-124a as a novel diagnostic and prognostic biomarker in non-small cell lung cancer for chemotherapy
It is demonstrated thatmiR-124a was downregulated in NSCLC, and miR- 124a was a potential prognostic tumor biomarker response to chemotherapy, and high expression of miR -124awith chemotherapy may increase OS.
MicroRNA‐328 is associated with (non‐small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration
Brain metastasis (BM) can affect ∼ 25% of nonsmall cell lung cancer (NSCLC) patients during their lifetime. Efforts to characterize patients that will develop BM have been disappointing. microRNAs
A sequence polymorphism in miR-608 predicts recurrence after radiotherapy for nasopharyngeal carcinoma.
The findings reveal rs4919510C > G in miR-608 as a simple marker to predict LRR in patients with radiotherapy-treated nasopharyngeal carcinoma.
MicroRNA-608 and MicroRNA-34a Regulate Chordoma Malignancy by Targeting EGFR, Bcl-xL and MET
It is demonstrated for the first time that microRNA-608 and miR-34a regulate chordoma malignancy by regulating EGFR, MET and Bcl-xL.