miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs

@article{Zhang2018miR608AM,
  title={miR-608 and miR-4513 significantly contribute to the prognosis of lung adenocarcinoma treated with EGFR-TKIs},
  author={Nasha Zhang and Yankang Li and Yan Zheng and Li Zhang and Yuan Pan and Jinming Yu and Ming Yang},
  journal={Laboratory Investigation},
  year={2018},
  volume={99},
  pages={568-576}
}
Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptors (EGFR) significantly prolong the survival of lung adenocarcinoma patients with sensitizing EGFR mutations. Unfortunately, 10–30% patients do not show objective responses to EGFR-TKIs, and undergo rapid disease progression during the EGFR-TKIs therapy. Single nucleotide polymorphisms (SNPs) in mature microRNA (miRNA) sequences may influence target site interactions and modulate downstream pathways, such as the EGFR… 
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Whether autophagy inhibition, along with anti-EGFR treatments, might represent a promising approach to overcome resistance to anti- EGFR treatments in various cancers is assessed.
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