miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer

@inproceedings{Ji2013miR5745pNR,
  title={miR-574-5p negatively regulates Qki6/7 to impact β-catenin/Wnt signalling and the development of colorectal cancer},
  author={Shunlong Ji and Gengtai Ye and Jun Zhang and Linpei Wang and Tao Wang and Zhen Wang and Tiantian Zhang and Guanghui Wang and Zongsheng Guo and Yu Luo and Jianchun Cai and James Y. Yang},
  booktitle={Gut},
  year={2013}
}
OBJECTIVE Deficiency or reduced expression of signal transduction and activation of RNA family protein Quaking (Qki) is associated with developmental defects in neural and vascular tissues and the development of debilitating human diseases including colorectal cancer (CRC). However, the mechanisms underlying the aberrant downregulation or deficiency of Qki were uncertain. DESIGN Expression of miR-574-5p, Qki5/6/7/7b splicing variants, β-catenin and p27(Kip1) was determined in mouse and human… CONTINUE READING
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