• Corpus ID: 195816735

miR 551 b Regulates Colorectal Cancer Progression by Targeting the ZEB 1 Signaling Axis

  title={miR 551 b Regulates Colorectal Cancer Progression by Targeting the ZEB 1 Signaling Axis},
  author={Kwang Seock Kim and Dongjun Jeong and Ita Novita Sari and Yoseph Toni Wijaya and Nayoung Jun and Sanghyun Lee and Ying-Gui Yang and Sae Hwan Lee and Hyog Young Kwon},
Our current understanding of the role of microRNA 551b (miR551b) in the progression of colorectal cancer (CRC) remains limited. Here, studies using both ectopic expression of miR551b and miR551b mimics revealed that miR551b exerts a tumor suppressive effect in CRC cells. Specifically, miR551b was significantly downregulated in both patient-derived CRC tissues and CRC cell lines compared to normal tissues and non-cancer cell lines. Also, miR551b significantly inhibited the motility of CRC cells… 
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