miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.

@article{Okamoto2012miR493ID,
  title={miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.},
  author={Koji Okamoto and Tatsuya Ishiguro and Yutaka Midorikawa and Hirokazu Ohata and Masashi Izumiya and Naoto Tsuchiya and Ai Sato and Hiroaki Sakai and Hitoshi Nakagama},
  journal={The EMBO journal},
  year={2012},
  volume={31 7},
  pages={1752-63}
}
Liver metastasis is a major lethal complication associated with colon cancer, and post-intravasation steps of the metastasis are important for its clinical intervention. In order to identify inhibitory microRNAs (miRNAs) for these steps, we performed 'dropout' screens of a miRNA library in a mouse model of liver metastasis. Functional analyses showed that miR-493 and to a lesser extent miR-493(*) were capable of inhibiting liver metastasis. miR-493 inhibited retention of metastasized cells in… CONTINUE READING
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