miR-486-5p inhibits cell growth of papillary thyroid carcinoma by targeting fibrillin-1.

@article{Ma2016miR4865pIC,
  title={miR-486-5p inhibits cell growth of papillary thyroid carcinoma by targeting fibrillin-1.},
  author={Xinfeng Ma and Jing Wei and Li Zhang and Deqiang Deng and Lianyong Liu and Xin Mei and Xiaohua He and Jianqing Tian},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year={2016},
  volume={80},
  pages={
          220-226
        }
}
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42 Citations
Background Citations
18
Methods Citations
1

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42 Citations

MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression.
MicroRNA-150 suppresses the growth and malignant behavior of papillary thyroid carcinoma cells via downregulation of MUC4
TLDR
It was demonstrated that miR-150 may serve a key function in suppressing the malignant growth and aggressive behavior of PTC cells through the downregulation of MUC4.
MicroRNA-486-5p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression
TLDR
Analysis indicated that miR-486-5p mimic transfection inhibited the proliferation, induced cell apoptosis and increased G1/S phase arrest of hHSFs by targeting Smad2, and may be a promising therapeutic target for HS management.
MiR-133b inhibits proliferation and invasion of gastric cancer cells by up-regulating FBN1 expression.
TLDR
The luciferase reporter assay proved that miR-133b directly targeted FBN1 and inhibits the proliferative, migratory and invasive abilities of GC cells by increasingFBN1 expression.
MiR-486-5p Act as a Biomarker in Endometrial Carcinoma: Promotes Cell Proliferation, Migration, Invasion by Targeting MARK1
Background miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of…
Role of miR‐486‐5p in regulating renal cell carcinoma cell proliferation and apoptosis via TGF‐β–activated kinase 1
TLDR
There are potential diagnosis and therapy values of miR‐486‐5p in RCC and it was shown that C‐C motif chemokine ligand 2 (CCL2) from tumor‐associated macrophages downregulated miR •486 •5p expression, and miR•486‐ 5p inhibited RCC cell proliferation and apoptosis resistance induced by CCL2.
DNA-methylation-mediated silencing of miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/β-catenin signal pathways
TLDR
It is demonstrated that miR-486-5p promotes colorectal cancer proliferation and migration through activation of PLAGL2/IGF2/β-catenin signal pathway, which is a promising therapeutic target of CRC treatment.
Downregulation of miR-486-5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing
TLDR
It may be hypothesized that miR-486-5p contributes towards PTC onset and progression, and may act as a clinical target, but in vitro and in vivo experiments are required to validate the findings of the present study.
YY1-induced up-regulation of FOXE1 is negatively regulated by miR-129-5p and contributes to the progression of papillary thyroid microcarcinoma.
KIAA1199, a Target of MicoRNA-486-5p, Promotes Papillary Thyroid Cancer Invasion by Influencing Epithelial-Mesenchymal Transition (EMT)
TLDR
The miR-486-5p/KIAA1199/EMT axis might play a critical role in PTC invasion and metastasis and offers a potential therapeutic strategy for PTC.
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References

SHOWING 1-10 OF 35 REFERENCES
Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer
We have previously shown that miR-486-5p is one of the most downregulated micro RNAs in lung cancer. The objective of the study was to investigate the role of miR-486-5p in the progression and…
miR-219-5p modulates cell growth of papillary thyroid carcinoma by targeting estrogen receptor α.
CONTEXT Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. It has been demonstrated that micro-RNAs (miRNAs) are involved in the development of PTC. The miRNA-chromatin…
MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes
TLDR
The found that miRNA-106b-5p was significantly upregulated in glioma tumor samples and cell lines compared with normal brain tissues, and its expression level correlated with the pathological grading, and these findings show the critical roles of miR- 106b- 5p and its targets, RBL1, R BL2 and CASP8, in gluoma tumorigenesis and provide potential candidates for malignant gliomas therapy.
miR-101 inhibits cell proliferation by targeting Rac1 in papillary thyroid carcinoma.
TLDR
Investigating the role of microRNA-101 in PTC via targeting of Ras-related C3 botulinum toxin substrate 1 showed that miR-101 was significantly downregulated in P TC tissues compared with adjacent normal tissues, providing a better understanding of miRNA-modulated signaling networks for future cancer therapeutics.
MicroRNA-30 b functions as a tumour suppressor in human colorectal cancer by targeting KRAS , PIK 3 CD and BCL 2
TLDR
Functional and mechanistic links between miRNA-30b and oncogene KRAS, PIK3CD and BCL2 in the pathogenesis of CRC were revealed and Restoration of miR-30B expression may represent a promising therapeutic approach for targeting malignant CRC.
MicroRNA-93 promotes cell growth and invasion in nasopharyngeal carcinoma by targeting disabled homolog-2.
MicroRNA‐486‐5p, which is downregulated in hepatocellular carcinoma, suppresses tumor growth by targeting PIK3R1
TLDR
It is concluded that miR‐486‐5p, which is frequently downregulated in HCC, inhibits HCC progression by targeting PIK3R1 and phosphatidylinositol 3‐kinase–AKT activation.
MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells.
MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors.
TLDR
A novel role is revealed in regulating normal hematopoiesis and of BCR-ABL-induced miR-486-5p overexpression in modulating CML progenitor growth, survival, and drug sensitivity.
MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1, and predicts poor patient survival (TUM2P.882)
TLDR
This work shows that miR-25 was overexpressed in plasma and primary tumor tissues of GC patients with TNM stage (III or IV) or lymph node metastasis, and promotes GC progress by directly down-regulating TOB1 expression, and the high concentrations of miR/μL in plasma ofGC patients predict poor patient survival.
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