miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.

  title={miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.},
  author={L. Pase and J. Layton and W. Kloosterman and D. Carradice and P. Waterhouse and G. Lieschke},
  volume={113 8},
  • L. Pase, J. Layton, +3 authors G. Lieschke
  • Published 2009
  • Biology, Medicine
  • Blood
  • We demonstrate that in zebrafish, the microRNA miR-451 plays a crucial role in promoting erythroid maturation, in part via its target transcript gata2. Zebrafish miR-144 and miR-451 are processed from a single precursor transcript selectively expressed in erythrocytes. In contrast to other hematopoietic mutants, the zebrafish mutant meunier (mnr) showed intact erythroid specification but diminished miR-144/451 expression. Although erythropoiesis initiated normally in mnr, erythrocyte maturation… CONTINUE READING
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