miR-451 regulates dendritic cell cytokine responses to influenza infection.

  title={miR-451 regulates dendritic cell cytokine responses to influenza infection.},
  author={Carrie M. Rosenberger and Rebecca L. Podyminogin and Garnet Navarro and Guo-wei Zhao and Peter S Askovich and Mitchell J Weiss and Alan Aderem},
  journal={Journal of immunology},
  volume={189 12},
MicroRNAs (miRNAs) are important posttranscriptional regulators in immune cells, but how viral infection regulates miRNA expression to shape dendritic cell (DC) responses has not been well characterized. We identified 20 miRNAs that were differentially expressed in primary murine DCs in response to the dsRNA agonist polyinosinic-polycytidylic acid, a subset of which were modestly regulated by influenza infection. miR-451 was unique because it was induced more strongly in primary splenic and… CONTINUE READING