miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells

@inproceedings{Noonan2010miR449aCR,
  title={miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells},
  author={Emily J. Noonan and Robert F. Place and Shashwati Basak and Deepa Pookot and Long-Cheng Li},
  booktitle={Oncotarget},
  year={2010}
}
MicroRNAs (miRNAs) are a class of small non-coding RNAs (ncRNAs) that regulate gene expression by repressing translation or triggering the degradation of complementary mRNA sequences. Certain miRNAs have been shown to function as integral components of the p53 and/or retinoblastoma (Rb) regulatory networks. As such, miRNA dysregulation can have a profound effect on cancer development. Previous studies have shown that miR-449a is down-regulated in human prostate cancer tissue and possesses… CONTINUE READING

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