miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas.

@article{Li2017miR4235pCT,
  title={miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas.},
  author={Shouwei Li and Ailiang Zeng and Qi Hu and Wei Yan and Yanwei Liu and Yongping You},
  journal={Neuro-oncology},
  year={2017},
  volume={19 1},
  pages={55-65}
}
BACKGROUND Gliomas are based on a genetic abnormality and present with a dismal prognosis. MicroRNAs (miRNAs) are considered to be important mediators of gene expression in glioma tissues. METHODS Real-time PCR was used to analyze the expression of microRNA-423-5p (miR-423-5p) in human glioma samples and normal brain tissue. Apoptosis, cell cycle, proliferation, immunostaining, transwell, in vitro 2D and 3D migration, and chemosensitivity assays were performed to assess the phenotypic changes… CONTINUE READING