miR-422a inhibits osteosarcoma proliferation by targeting BCL2L2 and KRAS

@inproceedings{Zhang2018miR422aIO,
  title={miR-422a inhibits osteosarcoma proliferation by targeting BCL2L2 and KRAS},
  author={Hao Zhang and Qian-Yun He and Guang-Chao Wang and Da-Ke Tong and Ren-Kai Wang and Wen-bin Ding and Cheng Zhen Li and Qiang Wei and Chen Ding and Pei-Zhao Liu and Hao-Chen Cui and Xin Zhang and Di Li and Hao Tang and Fang Ji},
  booktitle={Bioscience reports},
  year={2018}
}
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. However, the underlying mechanism of osteosarcoma carcinogenesis and progression remains unknown. In the present study, we evaluated the expression profile of miRNAs in osteosarcoma tissues and the adjacent normal tissues. We found that the expression of miR-422a was down-regulated in osteosarcoma tissues and cell lines. In addition, we observed significantly elevated levels of repressive H3K9me3 and… CONTINUE READING

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