miR-421 and miR-30c Inhibit SERPINE 1 Gene Expression in Human Endothelial Cells

  title={miR-421 and miR-30c Inhibit SERPINE 1 Gene Expression in Human Endothelial Cells},
  author={Alexandre Marchand and Carole Proust and Pierre Emmanuel Morange and A. M. Lompr{\'e} and David A Tr{\'e}gou{\"e}t},
  booktitle={PloS one},
In this work, we assessed whether SERPINE1 expression could be under the influence of microRNAs (miRNAs) predicted to bind the SERPINE1 3'UTR region. We specifically focused on the 3'UTR region harboring a common polymorphism, rs1050955, that have been found associated to SERPINE1 monocyte expression, and investigated whether the presence of different alleles at rs1050955 could modify the miRNAs binding efficiency and affect PAI-1 protein levels. We demonstrated that, in human umbilical vein… CONTINUE READING


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