miR-410 controls adult SVZ neurogenesis by targeting neurogenic genes.

@article{Tsan2016miR410CA,
  title={miR-410 controls adult SVZ neurogenesis by targeting neurogenic genes.},
  author={Yao-chang Tsan and Maria H Morell and Kathy Sue O'Shea},
  journal={Stem cell research},
  year={2016},
  volume={17 2},
  pages={238-247}
}
Over-expression of the early neural inducer, Noggin, in nestin positive subventricular zone (SVZ), neural stem cells (NSC) promotes proliferation and neuronal differentiation of neural progenitors and inhibits the expression of a CNS-enriched microRNA-410 (miR-410) (Morell et al., 2015). When expressed in neurospheres derived from the adult SVZ, miR-410 inhibits neuronal and oligodendrocyte differentiation, and promotes astrocyte differentiation. miR-410 also reverses the increase in neuronal… CONTINUE READING