miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts.

@article{Miao2015miR375RT,
  title={miR-375 regulates the canonical Wnt pathway through FZD8 silencing in arthritis synovial fibroblasts.},
  author={Cheng-gui Miao and Wei-jing Shi and You-yi Xiong and Hao Yu and Xiao-lin Zhang and Mei-song Qin and Chuan-lai Du and Tong-wen Song and Jun Li},
  journal={Immunology letters},
  year={2015},
  volume={164 1},
  pages={
          1-10
        }
}
Whether the rheumatoid arthritis (RA) pathogenesis is regulated by microRNA (miRNA) is not entirely clear. In this study, we found that miR-375 was down-regulated significantly in fibroblast-like synoviocytes (FLS) in adjuvant-induced arthritis (AIA) rat model compared with control. Because the web-based software TargetScan and PicTar predict Frizzled 8 (FZD8) as the target of miR-375, we investigated whether up-regulated miR-375 plays a role in the activation of the canonical Wnt signaling by… CONTINUE READING
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