miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells.

@article{Liu2013miR3715pDP,
  title={miR-371-5p down-regulates pre mRNA processing factor 4 homolog B (PRPF4B) and facilitates the G1/S transition in human hepatocellular carcinoma cells.},
  author={Rui-Yan Liu and Cai-feng Diao and Yi Zhang and Nan Wu and Hai-ying Wan and Xiang-yang Nong and Min Liu and Hua Tang},
  journal={Cancer letters},
  year={2013},
  volume={335 2},
  pages={351-60}
}
Increasing evidence has lent support to the notion that miRNAs regulate hepatocellular carcinoma (HCC) cell proliferation by directly targeting cell cycle-related genes. Among these genes, we identified PRPF4B, a CDK-like kinase, as a new target of miR-371-5p. Over-expression of miR-371-5p and knockdown of PRPF4B promotes cell growth by accelerating the G1/S transition in HCC cell lines. Moreover, miR-371-5p promotes tumor growth of QGY-7703 cells in vivo. Conversely, inhibition of miR-371-5p… CONTINUE READING
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