miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44.

@article{Zhao2013miR34aIT,
  title={miR-34a inhibits the metastasis of osteosarcoma cells by repressing the expression of CD44.},
  author={Haien Zhao and Bao'an Ma and Yucai Wang and Tao Han and Lianhe Zheng and Cong Sun and Tao Liu and Yinglong Zhang and Xiuchun Qiu and Qingyu Fan},
  journal={Oncology reports},
  year={2013},
  volume={29 3},
  pages={1027-36}
}
Osteosarcoma is the most common type of malignant bone tumor in children and adolescents and approximately 30% of patients develop lung metastasis, which is the leading cause of mortality. In this study, we investigated the role of miR-34a in the invasion and metastasis of osteosarcoma cells by examining its expression level and functional pattern in these cells. miR-34a mimics were transfected into the highly metastatic subline, F5M2… CONTINUE READING

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