miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells.

@article{Li2009miR34aIM,
  title={miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells.},
  author={Na Li and Hanjiang Fu and Yi Tie and Zheng Hu and Wei Kong and Yongge Wu and Xiaofei Zheng},
  journal={Cancer letters},
  year={2009},
  volume={275 1},
  pages={44-53}
}
Several studies have shown that miR-34a represses the expression of many genes and induces G1 arrest, apoptosis, and senescence. In the present study, we identified the role of miR-34a in the regulation of tumor cell scattering, migration, and invasion. Down-regulation of miR-34a expression was highly significant in 19 of 25 (76%) human hepatocellular carcinoma (HCC) tissues compared with adjacent normal tissues and associated with the metastasis and invasion of tumors. Furthermore, resected… CONTINUE READING
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