miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.

  title={miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.},
  author={Shyamal Dilhan Weeraratne and Vladimir M. Amani and Adrianne Neiss and Natalia Teider and Deborah K Scott and Scott L. Pomeroy and Yoon-Jae Cho},
  volume={13 2},
Recent studies have established miR-34a as a key effector of the p53 signaling pathway and have implicated its role in multiple cancer types. Here, we establish that miR-34a induces apoptosis, G2 arrest, and senescence in medulloblastoma and renders these cells more sensitive to chemotherapeutic agents. These effects are mediated in part by the direct post-transcriptional repression of the oncogenic MAGE-A gene family. We demonstrate that miR-34a directly targets the 3' untranslated regions of… CONTINUE READING
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Targeted Therapy in Medulloblastoma

  • Cho Y-J, SL Pomeroy
  • 2010

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