miR-342-5p Is a Notch Downstream Molecule and Regulates Multiple Angiogenic Pathways Including Notch, Vascular Endothelial Growth Factor and Transforming Growth Factor β Signaling.

@article{Yan2016miR3425pIA,
  title={miR-342-5p Is a Notch Downstream Molecule and Regulates Multiple Angiogenic Pathways Including Notch, Vascular Endothelial Growth Factor and Transforming Growth Factor β Signaling.},
  author={Xian-Chun Yan and Jing Cao and Liang Liang and Li Li Wang and Fang Gao and Zi-yan Yang and Juan-Li Duan and Tian-Fang Chang and San-Ming Deng and Yuan Liu and Guo-rui Dou and Jian Zhang and Qi-jun Zheng and Ping Zhang and Hua Han},
  journal={Journal of the American Heart Association},
  year={2016},
  volume={5 2}
}
BACKGROUND Endothelial cells (ECs) form blood vessels through angiogenesis that is regulated by coordination of vascular endothelial growth factor (VEGF), Notch, transforming growth factor β, and other signals, but the detailed molecular mechanisms remain unclear. METHODS AND RESULTS Small RNA sequencing initially identified miR-342-5p as a novel downstream molecule of Notch signaling in ECs. Reporter assay, quantitative reverse transcription polymerase chain reaction and Western blot… CONTINUE READING

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