miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.

Abstract

Recently, the inhibition of epithelial-mesenchymal-transition (EMT) by p53 has been described as a new mode of tumor suppression which presumably prevents metastasis. Here we report that activation of p53 down-regulates the EMT-inducing transcription factor SNAIL via induction of the miR-34a/b/c genes. Suppression of miR-34a/b/c caused up-regulation of… (More)
DOI: 10.4161/cc.10.24.18552

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