miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.

@article{Yang2014miR335PM,
  title={miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.},
  author={Dapeng Yang and Dominik Lutter and Ingo Burtscher and Lena Uetzmann and Fabian J. Theis and Heiko Lickert},
  journal={Development},
  year={2014},
  volume={141 3},
  pages={514-25}
}
Transcription factors (TFs) pattern developing tissues and determine cell fates; however, how spatio-temporal TF gradients are generated is ill defined. Here we show that miR-335 fine-tunes TF gradients in the endoderm and promotes mesendodermal lineage segregation. Initially, we identified miR-335 as a regulated intronic miRNA in differentiating embryonic stem cells (ESCs). miR-335 is encoded in the mesoderm-specific transcript (Mest) and targets the 3'-UTRs of the endoderm-determining TFs… CONTINUE READING
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