miR-335 inhibits small cell lung cancer bone metastases via IGF-IR and RANKL pathways.

@article{Gong2014miR335IS,
  title={miR-335 inhibits small cell lung cancer bone metastases via IGF-IR and RANKL pathways.},
  author={Meng Gong and Junrong Ma and Ryan Guillemette and Mingliang Zhou and Yan Yang and Yujing Yang and Janet M. Hock and Xijie Yu},
  journal={Molecular cancer research : MCR},
  year={2014},
  volume={12 1},
  pages={101-10}
}
UNLABELLED Small cell lung cancer (SCLC) is a rapidly progressing, incurable cancer that frequently spreads to bone. New insights are needed to identify therapeutic targets to prevent or retard SCLC metastatic progression. Human SCLC SBC-5 cells in mouse xenograft models home to skeletal and nonskeletal sites, whereas human SCLC SBC-3 cells only pervade nonskeletal sites. Because microRNAs (miRNA) often act as tumor regulators, we investigated their role in preclinical models of SCLC. miRNA… CONTINUE READING
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