miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity

@inproceedings{Allen2012miR33CT,
  title={miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity},
  author={Ryan M. Allen and Tyler J. Marquart and Carolyn J. Albert and Frederick J. Suchy and David Q-H Wang and Meenakshisundaram Ananthanarayanan and David Ford and {\'A}ngel Bald{\'a}n},
  booktitle={EMBO molecular medicine},
  year={2012}
}
Bile secretion is essential for whole body sterol homeostasis. Loss-of-function mutations in specific canalicular transporters in the hepatocyte disrupt bile flow and result in cholestasis. We show that two of these transporters, ABCB11 and ATP8B1, are functional targets of miR-33, a micro-RNA that is expressed from within an intron of SREBP-2. Consequently, manipulation of miR-33 levels in vivo with adenovirus or with antisense oligonucleotides results in changes in bile secretion and bile… CONTINUE READING
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