miR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2.

@article{Wang2016miR335pAN,
  title={miR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2.},
  author={Han Wang and Zhongyang Sun and Yixuan Wang and Zebing Hu and Hua Zhou and Lianchang Zhang and B Hong and Shuhong Zhang and Xinsheng Cao},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={23170}
}
MicroRNAs (miRNAs) interfere with the translation of specific target mRNAs and are thought to thereby regulate many cellular processes. However, the role of miRNAs in osteoblast mechanotransduction remains to be defined. In this study, we investigated the ability of a miRNA to respond to different mechanical environments and regulate mechano-induced osteoblast differentiation. First, we demonstrated that miR-33-5p expressed by osteoblasts is sensitive to multiple mechanical environments… CONTINUE READING
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