miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1

@article{Wu2013miR320RT,
  title={miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1},
  author={Yi-ying Wu and Yuh-Ling Chen and Yun-Chia Jao and I-Shan Hsieh and Kung-Chao Chang and Theodore S. Hong},
  journal={Angiogenesis},
  year={2013},
  volume={17},
  pages={247-260}
}
Tumor angiogenesis is a critical process during cancer progression that modulates tumor growth and metastasis. Here, we identified an anti-angiogenic microRNA, miR-320, which is decreased in oral squamous cell carcinoma (OSCC) cell lines and tumor tissues from OSCC patients, down-regulated in blood vessels and inversely correlated with vascularity in OSCC tissues. Neuropilin 1 (NRP1), an important regulator of angiogenesis, was found to be a target of miR-320. The 3′-untranslated region of NRP1… CONTINUE READING
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