miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation

  title={miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation},
  author={F. Xue and Hao Li and Jiguang Zhang and Jingjing Lu and Yunhong Xia and Qiao Xia},
  journal={Genes and Immunity},
MicroRNA (miRNA) has an important role as a master regulator of gene expression in immune system and is upregulated during T cell differentiation, however its function is not clear yet. In this study, the contribution of miR-31 in T cell activation was investigated. miR-31 was upregulated during the activation of primary T lymphocytes upon T-cell receptor (TCR) stimulation. Ectopic expression of miR-31 increased the expression of interleukin (IL)-2, while knockdown of endogenous miR-31… CONTINUE READING
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