miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo

@article{LesliePedrioli2010miR31FA,
  title={miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo},
  author={Deena M Leslie Pedrioli and Terhi Karpanen and Vasilios Dabouras and Giorgia Jurisic and Glenn van de Hoek and Jay W. Shin and Daniela Marino and Roland E K{\"a}lin and Sebastian A. Leidel and Paolo Cinelli and Stefan Schulte-Merker and Andr{\'e} W Br{\"a}ndli and Michael Detmar},
  journal={Molecular and Cellular Biology},
  year={2010},
  volume={30},
  pages={3620 - 3634}
}
ABSTRACT The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses, and promotes cancer metastasis. To address the role microRNAs (miRNAs) play in the development and function of the lymphatic vascular system, we defined the in vitro miRNA expression profiles of primary human lymphatic endothelial cells (LECs) and blood vascular endothelial cells (BVECs) and identified four BVEC signature and two LEC signature miRNAs. Their vascular lineage… 

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References

SHOWING 1-10 OF 69 REFERENCES

Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate

It is confirmed that Prox1 is a key player in the molecular pathway leading to the formation of lymphatic vasculature and identified as a master switch in the program specifying lymphatic endothelial cell fate, and that a single gene product was sufficient to re‐program the blood vascular endothelium toward a lymphatic phenotype.

Sox18 induces development of the lymphatic vasculature in mice

A critical role is demonstrated for Sox18 in developmental lymphangiogenesis, and new avenues to investigate for therapeutic management of human lymphangiopathies are suggested.

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor

It is found that isolated human primary lymphatic and blood vascular endothelial cells show interesting differences in gene expression relevant for their distinct functions in vivo, and overexpression of the homeobox transcription factor Prox‐1 in the BECs is suggested to act as a cell proliferation inducer and a fate determination factor for the LECs.

Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis.

Endothelial-specific molecule-1 (ESM-1) is revealed as a novel mediator of lymphangiogenesis and as a potential target for the inhibition of pathologic lymphatic vessel activation.

MicroRNA MiR-17 retards tissue growth and represses fibronectin expression

It is shown that overexpression of miR-17 results in decreased cell adhesion, migration and proliferation, and the single miRNA expression assay may be evolved to allow the manipulation of individual miRNA functions in vitro and in vivo.

Dicer Dependent MicroRNAs Regulate Gene Expression and Functions in Human Endothelial Cells

Results indicate that maintenance and regulation of endogenous miRNA levels via Dicer mediated processing is critical for EC gene expression and functions in vitro.

Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment.

The key importance of using precisely defined native ECs for the global identification of in vivo relevant cell functions is demonstrated by the identification of environment-dependent, EC subset-restricted gene expression regulates lineage fidelity, fluid exchange, and MHC class II-dependent antigen presentation.

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype

It is proposed that a blood vascular phenotype is the default fate of budding embryonic venous endothelial cells; upon expression of Prox1, these budding cells adopt a lymphatic vasculature phenotype.
...