miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo

  title={miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation In Vitro and Vascular Development In Vivo},
  author={Deena M Leslie Pedrioli and Terhi Karpanen and Vasilios Dabouras and Giorgia Jurisic and Glenn van de Hoek and Jay W. Shin and Daniela Marino and Roland E K{\"a}lin and Sebastian A. Leidel and Paolo Cinelli and Stefan Schulte-Merker and Andr{\'e} W Br{\"a}ndli and Michael Detmar},
  journal={Molecular and Cellular Biology},
  pages={3620 - 3634}
ABSTRACT The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses, and promotes cancer metastasis. To address the role microRNAs (miRNAs) play in the development and function of the lymphatic vascular system, we defined the in vitro miRNA expression profiles of primary human lymphatic endothelial cells (LECs) and blood vascular endothelial cells (BVECs) and identified four BVEC signature and two LEC signature miRNAs. Their vascular lineage… 

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