miR-30e targets IGF2-regulated osteogenesis in bone marrow-derived mesenchymal stem cells, aortic smooth muscle cells, and ApoE-/- mice.

@article{Ding2015miR30eTI,
  title={miR-30e targets IGF2-regulated osteogenesis in bone marrow-derived mesenchymal stem cells, aortic smooth muscle cells, and ApoE-/- mice.},
  author={Wen Jin Ding and Jihe Li and Jayanti Singh and Razan Alif and Roberto I. Vazquez-Padr{\'o}n and Samirah Abreu Gomes and Joshua M Hare and Lina A. Shehadeh},
  journal={Cardiovascular research},
  year={2015},
  volume={106 1},
  pages={131-42}
}
AIMS Activation of an osteogenic transcriptional program contributes to the initiation of aortic calcification in atherosclerosis. The role of microRNAs in regulating aortic calcification is understudied. We tested the hypothesis that miR-30e regulates an osteogenic program in bone marrow-derived mesenchymal stem cells (MSCs), aortic smooth muscle cells (SMCs), and ApoE(-/-) mice. METHODS AND RESULTS In aortas of wild-type mice, we found that miR-30e is highly expressed in medial SMCs. In… CONTINUE READING