miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.

@article{GazielSovran2011miR30b30dRO,
  title={miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.},
  author={Avital Gaziel-Sovran and Miguel F Segura and Raffaella Di Micco and Mary K. L. Collins and Douglas Hanniford and Eleazar Vega-Saenz de Miera and John F. Rakus and John F. Dankert and Shulian Shang and Robert S. Kerbel and Nina Bhardwaj and Yongzhao Shao and Farbod Darvishian and Jiri Zavadil and Adrian Erlebacher and Lara K Mahal and Iman Osman and Eva Hernando},
  journal={Cancer cell},
  year={2011},
  volume={20 1},
  pages={104-18}
}
To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by regulating multiple targets. We performed a microRNA analysis of human melanoma, a highly invasive cancer, and found that miR-30b/30d upregulation correlates with stage, metastatic potential, shorter time to recurrence, and reduced overall survival. Ectopic expression of miR-30b… CONTINUE READING

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