miR-30a negatively regulates TGF-β1-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting Snai1.

@article{Zhou2013miR30aNR,
  title={miR-30a negatively regulates TGF-β1-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting Snai1.},
  author={Qin Hai Zhou and Man Zhi Yang and Huiyao Lan and Xue-qing Yu},
  journal={The American journal of pathology},
  year={2013},
  volume={183 3},
  pages={808-19}
}
Although epithelial-mesenchymal transition (EMT) and the subsequent development of peritoneal fibrosis are key processes leading to the peritoneal failure related to peritoneal dialysis (PD), mechanisms underlying these processes remain largely unclear. In the present study, we found that miR-30a was significantly down-regulated in peritoneal tissues, with progressive fibrosis in patients with continuous ambulatory peritoneal dialysis and in a rat model of PD. In vitro, transforming growth… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 48 references

Advancing the use and quality of peritoneal dialysis by developing a peritoneal dialysis satellite center program.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis • 2011
View 3 Excerpts

TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29.

Journal of the American Society of Nephrology : JASN • 2011

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