miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD.

@article{He2016miR301aPI,
  title={miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD.},
  author={Chong He and Yan Shi and Ruijin Wu and Mingming Sun and Leilei Fang and Wei Wu and Changqin Liu and Maochun Tang and Zhongqiao Li and Ping Wang and Yingzi Cong and Zhanju Liu},
  journal={Gut},
  year={2016},
  volume={65 12},
  pages={1938-1950}
}
OBJECTIVE MicroRNA (miR)-301a is known to be involved in the tumourigenesis and pathogenesis of several autoimmune diseases, but it remains unclear whether miR-301a is associated with the pathogenesis of IBD. METHODS miR-301a expression was assessed in peripheral blood mononuclear cells (PBMC) and inflamed mucosa of patients with IBD by quantitative real-time-PCR. Peripheral blood CD4+ T cells were transduced with lentivirus-encoding pre-miR-301a (LV-miR-301a) or a reverse complementary… CONTINUE READING