miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer

@inproceedings{Yu2014miR300IE,
  title={miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer},
  author={Jingshuang Yu and Furong Xie and Xin Bao and Wantao Chen and Qin Xu},
  booktitle={Molecular Cancer},
  year={2014}
}
Epithelial-to-mesenchymal transition (EMT) is a key step of the progression of tumor cell metastasis. Recent work has demonstrated some miRNAs play critical roles in EMT. In this study, we focused on the roles of miR-300 in regulating EMT. The expression levels of miR-300 were examined in epithelial carcinoma cells that underwent an EMT using quantitative reverse transcription-PCR. The role of miR-300 in EMT was investigated by transfection of the miR-300 mimic or inhibitor in natural… CONTINUE READING
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