miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1.

@article{Zhang2012miR30IT,
  title={miR-30 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in hepatocyte by targeting Snail1.},
  author={Jingcheng Zhang and H Zhang and Junyu Liu and Xiaolong Tu and Yuhui Zang and Jie Zhu and Jiangning Chen and Lei Dong and Junfeng Zhang},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={417 3},
  pages={1100-5}
}
Epithelial-to-mesenchymal transition (EMT) has been implicated in embryonic development and various pathological events. Snail1 is a well-known E-cadherin-transcriptional repressor that is significantly upregulated during the TGF-β1-induced EMT in hepatocyte. However, the functional involvement of microRNA during the EMT process in hepatocyte remains to be determined. Here, we revealed that while the expression of Snail1 increased during the TGF-β1-induced EMT in AML12 murine hepatocytes, the… CONTINUE READING

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